Focus Rheums| Dr. Jekyll or Mr. Hyde? (video)

An official publication of the ACR and the ARP serving rheumatologists and rheumatology professionals

2015 ACR/ARHP Annual Meeting: Immune Mediators Can Impact Inflammatory Response

  |  Issue: March 2016  |  

PGE2 and eicosanoids are a previously unrecognized resident macrophage-specific source of inflammasome activation. When this eicosanoid response is dysregulated, it has severe consequences, and it’s a likely factor in innate immunity-driven diseases, Dr. Gronert said.

Susan Bernstein is a freelance medical journalist based in Atlanta.

ADVERTISEMENT
SCROLL TO CONTINUE

Second Chance

If you missed this session, it’s not too late. Catch it on SessionSelect.

References

  1. Proudman SM, James MJ, Spargo LD, et al. Fish oil in recent onset rheumatoid arthritis: A randomised, double-blind, controlled trial within algorithm-based drug use. Ann Rheum Dis. 2015 Jan;74(1):89–95. doi: 10.1136/annrheumdis-2013-204145. Epub 2013 Sep 30.
  2. Bjerregaard P, Young TK, Hegele RA. Low evidence of cardiovascular disease among the Inuit—What is the evidence? Atherosclerosis. 2003 Feb;166(2):351–357.
  3. Newson J, Stables M, Karra E, et al. Resolution of acute inflammation bridges the gap between innate and adaptive immunity. Blood. 11 Sep 2014;124(11):1748–1764. doi: 10.1182/blood-2014-03-562710. Epub 2014 Jul 8.
  4. Von Moltke J, Trinidad NJ, Moayeri M, et al. Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature. 2012 Oct 4;490(7418):107–111. doi: 10.1038/nature11351. Epub 2012 Aug 19.
ADVERTISEMENT
SCROLL TO CONTINUE

Related Articles

    Study Finds Eating Fresh Fish May Ease Rheumatoid Arthritis Symptoms

    Could relief for rheumatoid arthritis (RA) symptoms be as close as the nearest seafood restaurant? Possibly, say researchers from Harvard. University who recently conducted a cross-sectional study. Published in the March issue of Arthritis Care & Research, the research examined whether consuming fresh fish could ease RA symptoms.1 ad goes here:advert-1ADVERTISEMENTSCROLL TO CONTINUEPrevious studies have…

    2015 ACR/ARHP Annual Meeting: RA Pathogenesis and Prevention

    SAN FRANCISCO—Evolving research into the pathogenesis of rheumatoid arthritis (RA) is increasingly showing that rather than a single causative dysfunctional pathway leading to disease, multiple pathways are involved, the study of which can shed additional light on what is occurring in a person’s body prior to developing symptoms of disease. Saying it another way, no…

    Food for Thought: On Eating & Inflammation in Rheumatic Disease

    Certain nutrients or dietary patterns may affect inflammation and rheumatic disease risk in certain populations. Recommended nutrients include omega-3 fatty acids found in fish, poultry or nuts. Following a Mediterranean or standard Western diet may affect RA risk too.

    Food, Diet, Nutrition & Rheumatic Diseases—Are They Really Related?

    “‘I didn’t say there was nothing better,’ the King replied. ‘I said there was nothing like it.’” —Lewis Carroll, Through the Looking Glass “Why did I get this? Was it because of my diet? What should I eat now? What diet should I follow? Are there any natural treatments I can take instead of medications?”…