Bisphosphonates Reduce Bone Toughness Over Time

Dr. Burr adds, “It has been shown that the ‘half-life’ of bisphosphonates in bone may be 10 years. This means that once treatment is stopped, bone loss will not resume right away, and in fact may require 5–10 years for significant bone loss to occur [depending on the location, hip or vertebrae].”

Reference

1. Burr DB. Fifty years of bisphosphonates: What are their mechanical effects on bone? Bone. 2020 Sep;138:115518. Epub 2020 Jul 3.