Bone Density Concerns: Guidance on Tackling Fracture Risk in CKD

“CKD is not only a state of high PTH levels, but also a state of low PTH response,” he said. “It’s always the balance between [these states] that will, in the end, determine the bone phenotype—normal bone turnover, high or low bone turnover.”

Thomas R. Collins is a freelance writer living in South Florida.

References

Moe SM, Nickolas T. Fractures in patients with CKD: Time for action. Clin J Am Soc Nephrol. 2016 Nov 7;11(11):1929–1931.
Iimori S, Mori Y, Akita W, et al. Diagnostic usefulness of bone mineral density and biochemical markers of bone turnover in predicting fracture in CKD stage 5D patients—A single-center cohort study. Nephrol Dial Transplant. 2012 Jan;27(1):345–351.

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ACR CONVERGENCE 2020—Bisphosphonates are an important treatment for millions of older Americans with osteoporosis because the drugs inhibit osteoclastic bone resorption to reduce the risk of painful, debilitating fractures.1 More than 20 years ago, data emerged that bisphosphonates have a long terminal half-life.2 So after years of therapy, could some patients take a drug holiday?…

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