Key Takeaways
- Large granular lymphocytic (LGL) leukemia is a rare chronic lymphoproliferative disorder and up to one-third of patients have a concomitant diagnosis of rheumatoid arthritis;
- The risk of LGL leukemia in the development of osteoporosis and vertebral fractures is largely unknown, likely due to the rarity of the disorder; and
- An increase in RANKL receptor activation and upregulation of cytokines IL-6, IL-8 and TNF-α may contribute to the pathogenesis of LGL leukemia-associated vertebral compression fractures.
References
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- Marini C, Bruno S, Fiz F, et al. Functional activation of osteoclast commitment in chronic lymphocytic leukaemia: A possible role for Rank/RANKL pathway. Sci Rep. 2017 Oct 26;7(1):14159.
- Shvidel L, Duksin C, Tzimanis A, et al. Cytokine release by activated T-cells in large granular lymphocytic leukemia associated with autoimmune disorders. Hematol J. 2002;3(1):32–37.
- Diarra D, Stolina M, Polzer K, et al. Dickkopf-1 is a master regulator of joint remodeling. Nat Med. 2007 Feb;13(2):156–163.
- Van Staa TP, Leufkens HGM, Abenhaim L, et al. Oral corticosteroids and fracture risk: Relationship to daily and cumulative doses. Rheumatology (Oxford). 2000 Dec;39(12):1383–1389.
Authors’ Note
The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of Brooke Army Medical Center, the U.S. Army Medical Department, the U.S. Army Office of the Surgeon General, the Department of the Army, the Department of the Air Force, the Department of Defense or the U.S. government.
