Chikungunya Virus Vaccine Shows Promise in Early Clinical Trial

The research did not have commercial funding, but patents for the vaccine have been licensed by the National Institutes of Health to Emergent BioSolutions. Two of Dr. Chen’s coauthors were employees of Emergent BioSolutions.

References

Chen GL, Coates EE, Plummer SH, et al. Effect of a chikungunya virus-like particle vaccine on safety and tolerability outcomes: A randomized clinical trial. JAMA. 2020 Apr 14;323(14):1369–1377.
Stapleford KA, Mulligan MJ. A new vaccine for Chikungunya virus. JAMA. 2020 Apr 14;323(14):1351–1352.

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Doctors have had few options to treat the chronic rheumatoid arthritis-like symptoms associated with chikungunya virus infections beyond over-the-counter pain relievers. A recent study in Science Translational Medicine has spurred new optimism by finding that a combination therapy—the anti-rheumatic drug abatacept paired with a chikungunya-neutralizing monoclonal antibody—abolished acute symptoms in infected mice.1 The strategy must…

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