In a comparative clinical adhesion study in healthy subjects (N=44), ZTlido demonstrated superior adhesion (P<0.0001) to Lidoderm at 3 hours that improved over the 12-hour administration period.
In a separate clinical study, ZTlido demonstrated strong adhesive properties even during moderate exercise. Mild skin reactions are common with transdermal systems; reactions usually spontaneously resolve within a few minutes to hours. Allergic and anaphylactoid reactions associated with lidocaine rarely occurred.
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Michele B. Kaufman, PharmD, BCGP, is a freelance medical writer based in New York City and a pharmacist at New York Presbyterian Lower Manhattan Hospital.
References
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- Mowad C Cohen SF, Fussell NF, et al. Referral patterns to an osteoporosis clinic for dermatology patients undergoing prolonged corticosteroid therapy. J Am Acad Dermatol. 2018 Mar;78(3):591–592. doi: 10.1016/j.jaad.2017.01.058.
- Sorrento Therapeutics Inc. News release: ZTlido uses novel technology demonstrating 12-hour wear for efficient lidocaine delivery, even during exercise. 2018 Feb 28.