Maxillofacial surgery is often a last resource for severely affected patients for either functional or esthetic reasons. In the biologic era, the need for orthognathic surgery or joint replacement has decreased, and severe growth impairment, such as the bird-face appearance, is rarely seen. Maxillofacial surgical options include orthognathic surgery, distraction osteogenesis and TMJ reconstruction—autogenous or alloplastic. The TMJaw surgical group has developed surgical recommendations for JIA-associated TMJ arthritis describing the timing for the different options.13
Conclusion
JIA-associated TMJ arthritis occurs frequently and can have a devastating impact on TMJ function and facial growth and development.
Diagnosis is complicated by the need for a gadolinium-enhanced MRI to confirm the presence of active arthritis and to steer the right treatment. Facial signs and symptoms and dentofacial deformity may progress in well-treated patients.
Patients with TMJ arthritis should receive systemic treatment, and skeletally mature patients should receive intra-articular corticosteroid injections. Symptoms due to TMJ involvement, including TMJ dysfunction, can be treated with orthopedic devices, physiotherapy and, in extreme cases, with surgical intervention. Outcomes improve with early diagnosis and initiation of treatment.
To improve the oral, maxillofacial, health-related quality of life of our JIA patients, rheumatologists need to be aware of the potential involvement of the TMJs in JIA. Monitoring the TMJs during each clinic visit through a standardized clinical examination is necessary.
Marinka Twilt, MD, MSCE, PhD, is an assistant professor of pediatrics at the Cumming School of Medicine, University of Calgary, Alberta, Canada, and a pediatric rheumatologist at the Alberta Children’s Hospital, Calgary.
Peter B. Stoustrup, DDS, PhD, is an associate professor of orthodontics in the Section of Orthodontics, Aarhus University, Denmark.
References
- Stoustrup P, Twilt M, Spiegel L, et al. Clinical orofacial examination in juvenile idiopathic arthritis: International consensus-based recommendations for monitoring patients in clinical practice and research studies. J Rheumatol. 2017 15 Mar;44(3):326–333.
- Stoustrup P, Glerup M, Bilgrau AE, et al. Cumulative incidence of orofacial manifestations in early juvenile idiopathic arthritis: A regional, three-year cohort study. Arthritis Care Res (Hoboken). 2019 Apr 11. [Epub ahead of print]. doi: 10.1002/acr.23899
- Frid P, Nordal E, Bovis F, et al. Temporomandibular joint involvement in association with quality of life, disability, and high disease activity in juvenile idiopathic arthritis. Arthritis Care Res (Hoboken). 2017 May;69(5):677–686.
- Rahimi H, Twilt M, Herlin T, et al. Orofacial symptoms and oral health-related quality of life in juvenile idiopathic arthritis: A two-year prospective observational study. Pediatr Rheumatol Online J. 2018 Jul 13;16 (1):47.
- Stoustrup P, Resnick CM, Pedersen TK, et al. Standardizing terminology and assessment for orofacial conditions in juvenile idiopathic arthritis: International, multidisciplinary consensus-based recommendations. J Rheumatol. 2019 May;46(5):518–522.
- Hügle B, Spiegel L, Hotte J, et al. Isolated arthritis of the temporormandibular joint as the initial manifestation of juvenile idiopathic arthritis. J Rheumatol. 2017 Nov;44(11):1632–1635.
- Kellenberger CJ, Junhasavasdikul T, Tolend M, Doria AS. Temporomandibular joint atlas for detection and grading of juvenile idiopathic arthritis involvement by magnetic resonance imaging. Pediatr Radiol. 2018 Mar;48(3):411–426
- Bollhalder A, Patcas R, Eichenberger M, et al. Magnetic resonance imaging followup of temporomandibular joint inflammation, deformation, and mandibular growth in juvenile idiopathic arthritis patients receiving systemic treatment. J Rheumatol. 2019 Sep 15. [Epub ahead of print] doi:10.3899/jrheum.190168
- Lochbühler N, Saurenmann RK, Müller L, Kellenberger CJ. Magnetic resonance imaging assessment of temporomandibular joint involvement and mandibular growth following corticosteroid injection in juvenile idiopathic arthritis. J Rheumatol. 2015 Aug;42(8):1514–1522.
- Stoll ML, Amin D, Powell KK, et al. Risk factors for intraarticular heterotopic bone formation in the temporomandibular joint in juvenile idiopathic arthritis. J Rheumatol. 2018 Aug;45(9):1301–1307.
- Stoustrup P, Kuseler A, Kristensen KD, et al. Orthopaedic splint treatment can reduce mandibular asymmetry caused by unilateral temporomandibular involvement in juvenile idiopathic arthritis. Eur J Orthod. 2013 Apr;35(2):191–198.
- Stoustrup P, Kristensen KD, Kuseler A, et al. Management of temporomandibular joint arthritis-related orofacial symptoms in juvenile idiopathic arthritis by the use of a stabilization splint. Scand J Rheumatol. 2014;43(2):137–145.
- Resnick CM, Frid P, Norholt SE, et al. An algorithm for management of dentofacial deformity resulting from juvenile idiopathic arthritis: Results of a multinational consensus conference. J Oral Maxillofac Surg. 2019 Jun;77(6):1152.e1–1152.e33.