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E. Coli Linked to Crohn’s Disease-Associated Spondyloarthritis

Will Boggs, MD  |  

“The main message for physicians should be to focus less on microbiota changes but focus more on host response to this intestinal flora, at least in the context of inflammatory bowel diseases [IBD] and their extraintestinal complications,” Dr. Dubuquoy concludes. “This should help to choose more-targeted therapies.”

“Early detection of this immune response against AIEC appears an interesting marker to predict extraintestinal complication of [Crohn’s disease],” he adds. “This should allow the earlier use of targeted therapy and then increase its efficacy.”

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Reference

  1. Viladomiu M, Kivolowitz C, Abdulhamid A, et al. IgA-coated E. coli enriched in Crohn’s disease spondyloarthritis promote TH17-dependent inflammation. Sci Transl Med. 2017 Feb 8;9(376). pii: eaaf9655. doi: 10.1126/scitranslmed.aaf9655.

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