EULAR 2015: The Biology of Fatigue

Elsewhere, researchers have found that weakness can also be treated with an endurance training program. Cycling times increased after training in myositis patients, and importantly, lactate levels were found not to have risen and were even somewhat reduced.⁶

“Lactate is not higher, so it is not that the myositis patients improved their neuronal activation of muscles,” Dr. Westerblad said. “It must be that the muscles perform much better than they did before training.”

Thomas R. Collins is a freelance medical writer based in Florida.

References

1. Norheim KB, Harboe E, Gøransson LG, et al. Interleukin-1 inhibition and fatigue in primary Sjögren’s syndrome—A double blind, randomised clinical trial. PLoS One. 2012;7(1):e30123.
2. Carubbi F, Cipriani P, Marrelli A, et al. Efficacy and safety of rituximab treatment in early primary Sjögren’s syndrome: A prospective, multi-center, follow-up study. Arthritis Res Ther. 2013 Oct 30;15(5):R172.
3. Strand V, Burmester GR, Zerbini CA, et al. Tofacitinib with methotrexate in third-line treatment of patients with active rheumatoid arthritis: Patient-reported outcomes from a phase III trial. Arthritis Care Res (Hoboken). 2015 Apr;67(4):475–483.
4. Yamada T, Fedotovskaya O, Cheng AJ, et al. Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness. Ann Rheum Dis. 2014 May 22. pii: annrheumdis-2013-205007. doi: 10.1136/annrheumdis-2013-205007. [Epub ahead of print].
5. Yamada T, et al. Skeletal Muscle.
6. Alemo L, Munters M, Dastmalchi A, et al. Improved exercise performance and increased aerobic capacity after endurance training of patients with stable polymyositis and dermatomyositis. Arthritis Res Ther. 2013 Aug 13;15(4):R83.