appropriate testing and imaging tests. When there is a strong suspicion for malignancy, it may be appropriate to consider PET scanning. A marked elevation in the ratio of sIL-2R to ferritin may suggest the presence of lymphoma-associated HLH rather than HLH related to benign disease.
Anita Laloo, MB, BS, MPH, is a recent graduate of the Beth Israel Deaconess Medical Center Rheumatology Fellowship in Boston.
German Pihan, MD, is the chief of Diagnostic Hematopathology Service and director of the Hematopathology Fellowship Training Program at Beth Israel Deaconess Medical Center in Boston.
Robert H. Shmerling, MD, is the clinical chief of Rheumatology and Robinson Firm Chief at Beth Israel Deaconess Medical Center in Boston and a senior editor at Harvard Health Publications.
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