Samantha C. Shapiro, MD, is an academic rheumatologist and an affiliate faculty member of the Dell Medical School at the University of Texas at Austin. She is also a member of the ACR Insurance Subcommittee.
References
- Taylor PC, Fautrel B, Piette Y, et al. Physicians’ reasons for prescribing Janus kinase inhibitors (JAKi) in patients with rheumatoid arthritis, and associated alignment between physicians and patients in a real-world clinical setting [abstract]. Arthritis Rheumatol. 2021:73(suppl 10).
- Matsuno H. Treatment of rheumatoid arthritis with biological agents. In: Innovative Rheumatology, ed. Matsuno H. London: IntechOpen. 2013.
- Fleischmann R, Kremer J, Cush J, et al. Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. N Engl J Med. 2012 Aug 9;367(6):495–507.
- Burmester GR, Blanco R, Charles-Schoeman C, et al. Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: A randomised phase 3 trial. Lancet. 2013 Feb 9;381(9865):451–460.
- Taylor PC, Keystone EC, van der Heijde D, et al. Baricitinib versus placebo or adalimumab in rheumatoid arthritis. N Engl J Med. 2017 Feb 16;376(7):652–662.
- Flendrie M, Creemers MCW, Welsing PMJ, et al. Survival during treatment with tumour necrosis factor blocking agents in rheumatoid arthritis. Ann Rheum Dis. 2003 Nov;62(suppl 2):ii30–33.
- Pope J, Keystone E, Jamal S, et al. Persistence of tofacitinib in the treatment of rheumatoid arthritis in open-label, long-term extension studies up to 8 years [abstract]. Arthritis Rheumatol. 2016;68(suppl 10).
- Cohen SB, Tanaka Y, Mariette X, et al. Long-term safety of tofacitinib up to 9.5 years: A comprehensive integrated analysis of the rheumatoid arthritis clinical development programme. RMD Open. 2020 Oct;6(3):e001395.
- Winthrop K, Takeuchi T, Burmester G, et al. Safety profile of baricitinib for the treatment of rheumatoid arthritis up to 8.4 years: An updated integrated safety analysis [abstract]. Arthritis Rheumatol. 2020;72(suppl 10).
- Xie W, Huang Y, Xiao S, et al. Impact of Janus kinase inhibitors on risk of cardiovascular events in patients with rheumatoid arthritis: Systematic review and meta-analysis of randomised controlled trials. Ann Rheum Dis. 2019 Aug;78(8):1048–1054.
- Meissner Y, Albrecht K, Kekow J, et al. Risk of cardiovascular events under Janus kinase inhibitors in patients with rheumatoid arthritis: Observational data from the German RABBIT register. Ann Rheum Dis. 2022;81:86–87.
- Olivera PA, Lasa JS, Bonovas S, et al. Safety of Janus kinase inhibitors in patients with inflammatory bowel diseases or other immune-mediated diseases: A systematic review and meta-analysis. Gastroenterology. 2020 May;158(6):1554–1573.e12.
- Ytterberg SR, Bhatt DL, Mikuls TR, et al. Cardiovascular and cancer risk with tofacitinib in rheumatoid arthritis. N Engl J Med. 2022 Jan;386(4):316–326.
- Khosrow-Khavar F, Kim SC, Lee H, et al. Tofacitinib and risk of cardiovascular outcomes: results from the Safety of TofAcitinib in Routine care patients with Rheumatoid Arthritis (STAR-RA) study. Ann Rheum Dis. 2022 Jun;81(6):798–804.
- Losavio K. FDA requires new boxed warnings on JAK inhibitors, places restrictions on use. The Rheumatologist. 2021 Sep 1.
- Pfizer. XELJANZ safety review recommendation issued in the European Union. 2022 Jun 9.