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Mechanistic, Epidemiologic Clues Suggest Possible Link Between Obesity, Inflammation in Rheumatoid Arthritis

  |  Issue: October 2016  |  

Kurt Ullman is a freelance writer based in Indiana.

References

  1. Brestoff JR, Artis D. Immune regulation of metabolic homeostasis in health and disease. Cell. 2015 Mar 26;161(1):146–160.
  2. Ibid.
  3. Schipper HS, Prakken B, Kalkhoven E, Boes M. Adipose tissue-resident immune cells: Key players in immunometabolism. Trends Endocrinol Metab. 2012 Aug;23(8):407–415.
  4. Ibid.
  5. Voigt LF, Koepsell TD, Nelson JL, et al. Smoking, obesity, alcohol consumption, and the risk of rheumatoid arthritis. Epidemiology. 1994 Sep;5(5):525–532.
  6. Symmons DP, Bankhead CR, Harrison BJ, et al. Blood transfusion, smoking, and obesity as risk factors for the development of rheumatoid arthritis: Results from a primary care-based incident case-control study in Norfolk, England. Arthritis Rheum. 1997 Nov;40(11):1955–1961.
  7. Wesley A, Bengtsson C, Elkan AC, et al. Association between body mass index and anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis: Results from a population-based case-control study. Arthritis Care Res (Hoboken). 2013 Jan;65(1):107–112.
  8. Tedeschi SK, Cui J, Arkema EV, et al. Elevated BMI and ACPA interact to increase rheumatoid arthritis risk and shorten time to diagnosis: A nested case-control study of women in the Nurses’ Health Study. Semin Arthritis Rheum. 2016 (In Press).
  9. Qin B, Yang M, Fu H, et al. Body mass index and the risk of rheumatoid arthritis: A systematic review and dose-response meta-analysis. Arthritis Res Ther. 2015 Mar 29;17:86.
  10. Hu Y, Costenbader KH, Gao X, et al. Sugar-sweetened soda consumption and risk of developing rheumatoid arthritis in women. Am J Clin Nutr. 2014 Sep;100(3):959–967.
  11. Di Giuseppe D, Crippa A, Orsini N, Wolk A. Fish consumption and risk of rheumatoid arthritis: a dose-response meta-analysis. Arthritis Res Ther. 2014 Sep 30;16(5):446.
  12. Lu B, Solomon DH, Costenbader KH, Karlson EW. Alcohol consumption and risk of incident rheumatoid arthritis in women: A prospective study. Arthritis Rheumatol. 2014 Aug;66(8):1998–2005.
  13. Sparks JA, Iversen MD, Miller Kroouze R, et. al. Personalized risk estimator for rheumatoid arthritis (PRE-RA) family study: Rationale and design for a randomized controlled trial evaluating rheumatoid arthritis risk education to first-degree relatives. Contemp Clin Trials. 2014 Sep;39(1):145–157.
  14. Hu Y, Sparks JA, Costenbader KH, et al. Adherence to the dietary guidelines for Americans and risk of developing rheumatoid arthritis in young and middle-aged women [abstract]. Arthritis Rheumatol. 2015;67(suppl 10).
  15. Sparks JA, Halperin F, Karlson JC, et al. Impact of bariatric surgery on patients with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2015 Dec;67(12):1619–1626.
  16. Ajeganova S, Andersson ML, Hafström I, et al. Association of obesity with worse disease severity in rheumatoid arthritis as well as with comorbidities: A long-term followup from disease onset. Arthritis Care Res (Hoboken). 2013 Jan;65(1):78–87.
  17. Sparks JA, Olson AT, Halperin F, et al. Association of obesity with increased rheumatoid arthritis disease activity. Cardiovascular, Diabetes & Metabolic Disorders Research Center, Brigham Research Institute. Obesity Incubator Session, Boston, March 2016.

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