MUC5B Promoter Variant Associated with RA with Interstitial Lung Disease

The authors conclude their paper by proposing the MUC5B promoter variant may not only be a risk factor for idiopathic pulmonary fibrosis and RA with ILD, but may also be a more generalized risk factor for UIP disease.

In an accompanying editorial, Peter K. Gregersen, MD, professor of molecular medicine at the Feinstein Institute for Medical Research, Manhasset, N.Y., and Ellen M. Gravallese, MD, professor of medicine at the University of Massachusetts Medical School, Worcester, Mass., discuss whether all patients with RA should be evaluated for MUC5B carrier status given this new data.²

Lara C. Pullen, PhD, is a medical writer based in the Chicago area.

References

Juge PA, Lee JS, Ebstein E, et al. MUC5B promoter variant and rheumatoid arthritis with interstitial lung disease. N Engl J Med. 2018 Oct 20. [Epub ahead of print]
Gregersen PK, Gravallese EM. Breathing new life into interstitial lung disease in rheumatoid arthritis. N Engl J Med. 2018 Oct 20. [Epub ahead of print]

Patients with systemic sclerosis (SSc), poly-/dermatomyositis (PM/DM), or rheumatoid arthritis (RA) appear to carry the greatest risk for developing connective tissue disease-associated interstitial lung disease (CTD-ILD)

No one-size-fits-all approach exists for the care and treatment of patients with systemic sclerosis (SSc) and SSc with pulmonary involvement. Here, experts discuss some best clinical practices for these patients.

MADRID—Rheumatoid arthritis (RA) is among the most common autoimmune diseases in the U.S., affecting approximately 1.3 million U.S. adults.1 Although tremendous treatment advances have been made in recent years, one extra-articular manifestation of RA that continues to pose a challenge with regard to detection and management is interstitial lung disease (ILD). At the 2019 European…

Detecting interstitial lung disease in RA patients can be challenging. But evaluating risk factors and the use of imaging can help clinicians identify and manage this condition in patients…

What Rheumatologists Need to Know about Diagnosing and Managing Interstitial Lung Disease (ILD)

Scleroderma & ILD: Practical Tips on the Diagnosis & Management of Systemic Sclerosis-Associated Interstitial Lung Disease

Insights into Interstitial Lung Disease in Rheumatoid Arthritis Patients

Catch Your Breath: Insights into ILD in RA Patients

Related Articles