New Insights into the Structure of Collagen Fibril

“Our data suggest that fiber breakdown during osteoarthritis initially occurs by ‘unbundling’ of prototypic fibrils, suggesting a potential target for therapy,” write the authors.

Lara C. Pullen, PhD, is a medical writer based in the Chicago area.

Reference

Gottardi R, Hansen U, Raiteri R, et al. Supramolecular organization of collagen fibrils in healthy and osteoarthritic human knee and hip joint cartilage. PLoS One. 2016 Oct 25;11(10):e0163552. doi: 10.1371/journal.pone.0163552. eCollection 2016.

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