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PAD2 & PAD4 Modulate Immune Response in TLR-7-Dependent Lupus

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The researchers conclude that targeting PAD2 and/or PAD4 activity in patients with lupus may affect innate and adaptive immunity and modulate dysregulated TLR-7-dependent immune responses.

Lara C. Pullen, PhD, is a medical writer based in the Chicago area.

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Reference

  1. Liu Y, Lightfoot YL, Seto N, et al. Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus. JCI Insight. 2018 Dec 6;3(23). pii: 124729. [Epub ahead of print]

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