(Reuters)—AstraZeneca’s experimental drug anifrolumab failed to meet its main target in a late-stage clinical study treating patients with moderate to severe lupus, the British drugmaker said on Friday. AstraZeneca said the drug did not meet the main goal in the final-stage of one of the two clinical trials under the TULIP program, failing to show…
Insight into Endothelial Dysfunction in Early SLE Patients without Cardiovascular Disease
The early identification of endothelial dysfunction may be useful in clinical practice to prevent SLE patients from developing atherosclerosis and cardiovascular disease. New research evaluated the use of peripheral arterial tonometry in assessing endothelial dysfunction in patients with early SLE and no cardiovascular risk factors or disease. The results: These patients showed a high rate of endothelial dysfunction and vascular stiffness…
Investigators Assess Infection Risk with RA Biologics
Due to a range of factors, determining the precise infection risk posed by new biologic therapies to RA patients is difficult. But progress has been made and health registries may be helpful, said Olivier Lortholary, MD, PhD, during the 2018 EULAR: Annual European Congress of Rheumatology…
Advocate for Prompt Vasculitis Diagnosis & Treatment
Rheumatologists can act as advocates for patients and their families in a way that supports targeting vasculitis early. Here’s how…
Distinct DNA Methylation Patterns Associated with Myalgic Encephalomyelitis
New research explores the genome-wide epigenetic changes associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The results suggest distinct patterns in DNA methylation may become a useful diagnostic marker…
Oklahoma Medicaid Tests New Tactic to Curb U.S. Drug Costs
LOS ANGELES (Reuters)—A new front in the battle over the cost of expensive medicines in the United States is opening up in Oklahoma, the first state where the government’s Medicaid program is negotiating contracts for prescription drugs based on how well they work. In June, Oklahoma received approval from the U.S. Centers for Medicare and…
Critieria, Pathogenesis Highlight New Lupus Efforts
Clinicians and researcher are gaining tools and insights into SLE, with newly proposed classification criteria and new findings on SLE pathogenesis presented at the 2018 EULAR: Annual European Congress of Rheumatology…
New Research Provides Insight into Neurosarcoidosis
New research into neurosarcoidosis suggests certain clinical and imaging features are indicative of a more aggressive neurological disease. The study provides insight into the clinical features of neurosarcoidosis, as well as the relationship between neurological involvement and systemic disease…
Art Tours May Have Analgesic Effect for Chronic Pain Patients
(Reuters Health)—Art museums may have an analgesic effect on chronic pain, a small study suggests. Chronic pain sufferers who took guided tours of art museums felt less discomfort and unpleasantness related to their pain shortly afterward, researchers found. The researchers invited 54 visitors to the Crocker Art Museum in Sacramento, Calif., who reported experiencing chronic…
Adalimumab May Help Maintain Remission in Non-Radiographic Axial Spondyloarthritis
NEW YORK (Reuters Health)—In patients with active non-radiographic axial spondyloarthritis (nr-axSpA) who achieved remission while taking adalimumab, researchers saw fewer flares among those who continued taking the drug than among those who stopped taking it. “The results showed that continued therapy with adalimumab was associated with a higher rate of maintenance of remission compared with…
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