(Reuters Health)—Telling patients about their genetic risk for disease doesn’t usually lead to healthy behavior changes, such as eating better or exercising more, according to a new analysis of existing studies. Researchers selected 18 studies that tracked seven potential behavior changes—such as quitting smoking, diet, physical activity and using sun protection—among people who had received…
Plaque Psoriasis: Secukinumab Beats Ustekinumab in a Head-to Head Clinical Trial & Ixekizumab Helps Improve Productivity
In a 52-week clinical trial, patients with plaque psoriasis who took secukinumab achieved greater sustained skin clearance then those taking ustekinumab. Also, three clinical trials showed ixekizumab improves work productivity in patients with plaque psoriasis…
Fibromyalgia & Bipolar Spectrum Disorder: A Shared Pathophysiology May Lead to Better Drug Targets
Patients suffering from fibromyalgia and those suffering from bipolar spectrum disorder experience similar symptoms. Research suggests that these diseases may share a pathophysiological process, particularly a similar impairment in the prefrontal-limbic networks of the brain. A new editorial addresses how a better understanding of the potential shared biological underpinning of these diseases could result in unique drug targets…
U.S. Agency Issues New Guidelines to Limit Chronic Use of Opioids
(Reuters)—Addressing a growing “epidemic” of opioid overdoses and abuse of the prescribed painkillers in the U.S., the Centers for Disease Control and Prevention on Tuesday released voluntary guidelines that instruct primary care doctors to sharply deter use of the medicines for chronic pain. “Overprescribing opioids, largely for chronic pain, is a key driver of America’s…
Careful Collaboration: 5 Tips for Participating in Clinical Trials
For rheumatologists, research is important, but some clinical trials may not be worth collaborating on. In a recent interview, Hermine Brunner, MD, MSc, MBA, FACR, outlined important considerations to make when deciding to participate in a clinical trial to ensure a good fit…
Psoriasis Drug Succeeds in Mid-Stage Study
(Reuters)—Drug developer Vitae Pharmaceuticals Inc. said its experimental psoriasis drug significantly reduced the skin condition in patients from a mid-stage trial, sending its shares up 70% in after-hours trading. Patients taking a 350 mg dose of the drug, VTP-43742, showed a 24% reduction, while patients who took the 700 mg dose showed a 30% reduction…
Johnson & Johnson Hit with $500 Million Verdict in Trial over Hip Implants
NEW YORK (Reuters)—Johnson & Johnson and its DePuy unit were ordered by a Texas federal jury on Thursday to pay a total of about $500 million to five plaintiffs who said they were injured by Pinnacle metal-on-metal hip implants. Following a two-month trial, jurors found that the Pinnacle hips were defectively designed, and that the…
Smartphones Not So Smart with Urgent Medical Questions
(Reuters Health)—Smartphones are the first thing many people turn to with questions about their health. But when it comes to urgent queries about issues like suicide, rape and heart attack, phones can be pretty bad at offering good medical advice, a new study suggests. Researchers tested four commonly used conversation agents that respond to users’…
Clinical Trials: Zilretta Promising for Knee OA Pain & Golimumab Completes Phase 3 Trial
In recent Phase 3 clinical trials, Zirletta proved effective in managing pain for patients with knee osteoarthritis, and subcutaneous golimumab helped patients with psoriatic arthritis achieve long-term functional improvement…
Trying to Parse True Meaning of Pain Can Be Challenging for Rheumatologists
Discussing aching joints, sore muscles and tender limbs is all in our day’s work. We are rheumatologists; we deal in misery. But trying to parse the true meaning of these terms is among the most vexing of clinical challenges.
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