SAN FRANCISCO—A 40-year-old woman shows up in the clinic with scarring alopecia, with an area of hyperpigmentation on the rim of her scalp, extending from just behind the temple to behind her ears. An examination with a dermatoscope shows hyperkeratotic follicular plugging. The case—in this example, the discoid form of cutaneous lupus erythematosus (DLE)—is one…
U.S. Proposes Hike in Medicare Advantage Payments; Insurer Shares Rise
NEW YORK (Reuters)—The U.S. government on Friday proposed raising payments by 1.35% on average next year to the health insurers who offer Medicare Advantage health benefits to elderly and disabled Americans. Payments to insurers will vary under the 2017 Medicare Advantage proposal, based on the region the plans are sold and on the size of…
Scientists Find How ‘Superbugs’ Build Their Defenses
LONDON (Reuters)—Scientists in Britain have found how drug-resistant bacteria build and maintain a defensive wall—a discovery that paves the way for the development of new drugs to break through the barrier and kill the often deadly “superbugs.” In recent decades, bacteria resistant to multiple drugs, such as methicillin-resistant Staphylococcus aureus (MRSA) or Clostridium difficile, have…
Insight into Crosstalk Between Bone & Immune Systems
Osteoimmunology is an emerging field that focuses on the interaction between bone and the immune system. CD4+ T cells play an important role in the bone marrow and modulate the differentiation of bone-resorbing osteoclasts. This article reviews the role of CD4+ T cells as an osteoclastogenic population in inflammatory bowel disease…
Los Angeles Hospital Paid Hackers $17,000 Ransom in Bitcoins
(Reuters)—The president of Hollywood Presbyterian Medical Center said on Wednesday that his hospital paid hackers a ransom of $17,000 in bitcoins to regain control of their computer systems after a cyber attack. Allen Stefanek said in a statement that paying the ransom was the “quickest and most efficient way” of regaining access to the affected…
Route of Iron Replacement Doesn’t Impact IBD Activity, Quality of Life
NEW YORK (Reuters Health)—The route of iron replacement therapy alters the gut microbiome and metabolomics in patients with inflammatory bowel disease (IBD), but the route is unrelated to disease activity and quality of life, according to a new study. “Crohn’s disease patients are extremely fragile to disturbances and one might speculate about consequences in long-term…
Market Turmoil Drives Small Biotechs to Big Pharma
(Reuters)—Numerous small biotechnology companies have been all but shut out of the capital markets, leaving many with no choice but to consider a sale to larger peers. The Nasdaq Biotech Index is down nearly 30% since September, when Democratic presidential candidate Hillary Clinton criticized drug companies’ “price gouging” on Twitter and sparked concerns about a…
Pfizer Unit to Pay $784.6 Million in Medicaid Rebate Settlement
(Reuters)—Pfizer Inc. said its Wyeth unit has agreed to pay $784.6 million to settle cases related to the calculation of Medicaid rebates for a gastric drug between 2001 and 2006. The claims alleged that Wyeth’s calculation of rebates for its proton pump inhibitor Protonix (pantoprazole) violated the Federal Civil False Claims Act and other laws…
2015 ACR/ARHP Annual Meeting in Photos
San Francisco, Nov. 6–11, 2015 The 2015 ACR/ARHP Annual Meeting in San Francisco was the most well attended in the College’s history. With the poster hall, exhibit hall, concurrent scheduling of multiple tracks and hundreds of scientific sessions presented during the event, the odds are good that even attendees missed a lot of what they…
2015 ACR/ARHP Annual Meeting: T Follicular Helper Cells Emerge as Potential Treatment Target for Autoimmune Diseases
SAN FRANCISCO—T follicular helper (Tfh) cells are emerging as an important subset of cells now recognized as important to facilitating an adaptive immune response. Developed during dendritic cell priming in vivo, these cells represent one subgroup among many of effector cells that result after naive CD4+T cells differentiate. Other well-known subgroups include Th1 cells, Th2…
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