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An official publication of the ACR and the ARP serving rheumatologists and rheumatology professionals

Pediatric Rheumatology Year in Review, 2021: Basic Science

Elizabeth Sloan, MD  |  

Elizabeth Sloan, MD, is an instructor in the Division of Pediatric Rheumatology, UT Southwestern Medical Center, Dallas, where she also completed her rheumatology fellowship. Dr. Sloan has served on the ACR’s Special Committee on Pediatric Rheumatology, as well as the Fellows-in-Training Subcommittee of the Committee on Rheumatology Training and Workforce Issues.

References

  1. Barturen G, Babaei S, Català-Moll F, et al. Integrative analysis reveals a molecular stratification of systemic autoimmune diseases. Arthritis Rheumatol. 2021 Jun;73(6):1073–1085.
  2. Caielli S, Cardenas J, de Jesus AA, et al. Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE. Cell. 2021 Aug;184(17):4464–4479.e19.
  3. Tsuchiya K, Hosojima S, Hara H, et al. Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes. Cell Rep. 2021 Mar 23;34(12):108887.
  4. Levescot A, Chang MH, Schnell J, et al. IL-1β-driven osteoclastogenic Tregs accelerate bone erosion in arthritis. J Clin Invest. 2021 Sep 15;131(18):e141008.
  5. Loske J, Röhmel J, Lukassen S, et al. Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children. Nat Biotechnol. 2021 Aug 18;10.1038/s41587-021-01037-9. Online ahead of print.
  6. Lim AI, McFadden T, Link VM, et al. Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring. Science. 2021 Aug 27;373(6558):eabf3002.
  7. Taft J, Markson M, Legarda D, et al. Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death. Cell. 2021 Aug 19;184(17):4447–4463.e20.
  8. Jee H, Huang Z, Baxter S, et al. Comprehensive analysis of ADA2 genetic variants and estimation of carrier frequency driven by a function-based approach. J Allergy Clin Immunol. 2021 May 15;S0091-6749(21)00733-8. Online ahead of print.

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