Polymyalgia Rheumatica Rapid Symptom Improvement After Glucose Is Controlled

“It has been known for some time that some diabetes drugs, including repaglinide, may have anti-inflammatory properties in nondiabetic animals, but doses required for clinical efficacy belie a practical application. Before considering a clinical trial of diabetes management in patients presenting with the polymyalgic syndrome, which may risk harm from poorly managed disease, a more definitive epidemiologic study should be considered. In my opinion, there isn’t evidence of an important pathogenetic link between PMR and diabetes,” he says.

Reference

1. Yoshida K, Sakamoto N, Kurosaka D. Improvement in polymyalgia rheumatica associated with improved control of diabetes mellitus: A case series. Ann Intern Med. 2020 Sep 15. doi: 10.7326/L20-0196. Online ahead of print.