Looking Ahead
Many logistical, financial and ethical questions may arise in the future as we seek to prevent the onset of clinical disease. If a high-risk genetic profile for RA is known at birth or early in life, how soon is too soon to attempt preventive treatment? What is the cost to individuals and to society in expanding the use of conventional synthetic and biologic disease-modifying anti-rheumatic drugs to those without clinical disease, some of whom may never manifest clinical symptoms?
ad goes here:advert-1
ADVERTISEMENT
SCROLL TO CONTINUE
Although the field is young, preventive rheumatology may increasingly become part of the medical landscape, and it is worthwhile to better explore this field and see what the future has in store.
Jason Liebowitz, MD, completed his fellowship in rheumatology at Johns Hopkins University, Baltimore, where he also earned his medical degree. He is currently in practice with Skylands Medical Group, N.J.
References
ad goes here:advert-2
ADVERTISEMENT
SCROLL TO CONTINUE
- Deane KD, Demoruelle MK, Kelmenson LB, et al. Genetic and environmental risk factors for rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2017 Feb; 31(1):3–18.
- Rantapää-Dahlqvist S, de Jong BAW, Berglin E, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003 Oct;48(10):2741–2749.
- Kelmenson LK, Wagner BD, McNair BK, et al. Timing of elevations of autoantibody isotypes prior to diagnosis of rheumatoid arthritis. Arthritis Rheumatol. 2020 Feb;72(2):251–261.
- van de Stadt LA, Witte BI, Bos WH, van Schaardenburg D. A prediction rule for the development of arthritis in seropositive arthralgia patients. Ann Rheum Dis. 2013 Dec;72(12):1920–1926.
- Gerlag DN, et al. Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: The PRAIRI study. Ann Rheum Dis. 2019 Feb;78(2):179–185.