Researchers Find the Switch that Underlies Macrophage Metabolism

In conclusion, the study revealed that the switch from a Myc-dependent to a HIF1α-dependent transcriptional program appears to regulate the robust bioenergetics support required for an inflammatory response. The switch allows for a rapid response to infection while simultaneously sparing Myc-dependent proliferation.

Lara C. Pullen, PhD, is a medical writer based in the Chicago area.

Reference

Liu L, Lu Y, Martinez J, et al. Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent. Proc Natl Acad Sci USA. 2016 Feb 9;113(6):1564-9. doi: 10.1073/pnas.1518000113. Epub 2016 Jan 25.

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