Chinese studies of rheumatic disease have made substantial achievements. From the early epidemiologic study of Sjögren’s syndrome to further characterization of the clinical phenotypes and immunologic profiles of the Chinese patients, to the GWAS study, clinical and translational research on Sjögren’s syndrome has made huge progress.4,5
Registries generate patient benefit in the era of big data, such as the Chinese SLE Treatment and Research Group (CSTAR), a national registry of patient clinical data and blood biobank with 104 participating centers since its establishment in 2009.6 The Chinese Registry of Rheumatoid Arthritis (CREDIT) has also been established.7
A long-term clinical study of the Chinese traditional drug Tripterygium wilfordii Hook F in rheumatic disease and a recent randomized clinical trial show the herbal remedy is “not inferior to methotrexate,” and even better when employed in combination with methotrexate in controlling rheumatoid arthritis disease activity.8
Moving Forward
In the U.S., there are approximately 300 million people, and 5,500–6,000 full-time rheumatologists or providers; this means that there are 1.61–3.07 providers per 100,000 people.9 In China, there are 1.4 billion people and 8.61 million physicians, including 7,197 rheumatologists or rheumatology providers. It is estimated that China may have 0.2 billion patients with rheumatic diseases.
It is imperative to train more rheumatologists and physicians with a special interest in rheumatology to increase the Chinese rheumatology workforce. To provide high-quality care, the CRA has begun to develop national guidelines for the treatment and management of common rheumatic diseases, such as rheumatoid arthritis and gout.
Xiaofeng Zeng, MD, is a professor of medicine and chief of the Department of Rheumatology and Immunology at Peking Union Medical College Hospital, and current president of the Chinese Rheumatology Association, Beijing, China.
Qingping Yao, MD, PhD, is a professor in the Department of Medicine and chief of the Division of Rheumatology, Allergy and Immunology, at Stony Brook University School of Medicine, Stony Brook, N.Y.
Acknowledgment
The authors thank Dr. Min Shen for her coordination and review of this article.
References
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- Zeng QY, Chen R, Darmawan J, et al. Rheumatic diseases in China. Arthritis Res Ther. 2008;10(1):R17.
- Zhang NZ, Shi CS, Yao QP, et al. Prevalence of primary Sjogren’s syndrome in China. J Rheumatol. 1995 Apr;22(4):659–661.
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- Li Y, Zhang K, Chen H, et al. A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjogren’s syndrome at 7q11.23. Nat Genet. 2013 Nov;45(11):1361–1365.
- Leng X, Li M, Li X, et al. Chinese lupus treatment and research group (CSTAR) registry: X. family history in relation to lupus clinical and immunological manifestations. Clinical and experimental rheumatology. Clin Exp Rheumatol. 2018 Jan–Feb;36(1):81–87.
- Jin S, Li M, Fang Y, et al. Chinese Registry of rheumatoid arthritis (CREDIT): II. prevalence and risk factors of major comorbidities in Chinese patients with rheumatoid arthritis. Arthritis Res Ther. 2017 Nov 15;19(1):251.
- Lv QW, Zhang W, Shi Q, et al. Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): A randomised, controlled clinical trial. Ann Rheum Dis. 2015 Jun 7;74(6):1078–1086.
- Battafarano DF, Ditmyer M, Bolster MB, et al. 2015 American College of Rheumatology workforce study: Supply and demand projections of adult rheumatology workforce, 2015–2030. Arthritis Care Res (Hoboken). 2018 Apr;70(4):617–626.