Exclusive: ACR Convergence 2024| Focus Rheums

An official publication of the ACR and the ARP serving rheumatologists and rheumatology professionals

Rheuminations: Ankylosing Spondylitis Sometimes Defies Detection

  |  Issue: May 2014  |  

Henry C. Barry, MD, MS, professor, Michigan State University, East Lansing.
Copyright© 2014 John Wiley & Sons, Inc.

References

  1. Boland EW, Present AJ. Rheumatoid spondylitis. A study of one hundred cases, with special reference to diagnostic criteria. JAMA. 1945;129:843–846.
  2. Spencer DG, Sturrock RD, Buchanan WW. Ankylosing spondylitis: Yesterday and today. Medical History. 1980;24:60–69.
  3. Richmond JJ. The importance of radiotherapy in the treatment of ankylosing spondylitis. Proc Roy Soc Med. 1951;44:443–447.
  4. More than a doctor. A life guide to ankylosing spondylitis. Video posted Feb. 4, 2014. http://www.everydayhealth.com/health-report/sanjay-gupta/a-life-guide-to-ankylosing-spondylitis.aspx.
  5. Khan MA. Remarkable polymorphism of HLA-B27: An ongoing saga. Curr Rheumatol Rep. 2010;12:337–341.
  6. Thorsby E. HL-A antigens and genes. A study of unrelated Norwegians. Vox Sang. 1969;17:81–92.
  7. Gofton JP, Robinson HS, Price GE. A study of rheumatic disease in a Canadian Indian population. Ann Rheum Dis. 1964;23:364–371.
  8. Brewerton, DA. Discovery: HLA and disease. Curr Opin Rheum. 2003;15: 369–373.
  9. Cheidel S, Chen L, Pointon J, et al. ERAP1 and ankylosing spondylitis. Curr Opin Immunol. 2013;25:97–102.
  10. van Hoeven L, Luime J, Han H, et al. Identifying axial spondyloarthritis in Dutch primary care patients, ages 20–45 years with chronic low back pain. Arthritis Care Res. 2014;66:446–453.

ADVERTISEMENT
SCROLL TO CONTINUE

Related Articles
    How HLA-B27 Research Landmarks, Advances Relate to Ankylosing Spondylitis Pathogenesis

    How HLA-B27 Research Landmarks, Advances Relate to Ankylosing Spondylitis Pathogenesis

    The mechanistic link between human leukocyte antigen B27 (HLA-B27) and ankylosing spondylitis (AS) is one of the great enigmas in rheumatology. The introduction of biological therapies that target tumor necrosis factor (TNF) or the interleukin (IL) 23/IL-17A axis has had a major impact on the quality of life for many patients with AS, and one…

    Conformational Flexibility in HLA-B27 Provides Clues to Development of Ankylosing Spondylitis

    Understanding how human leukocyte antigen (HLA) class I molecule B27 promotes spondyloarthritis has intrigued researchers for four decades. Although the association between the single gene variant HLA-B27—specifically some of its subtypes—with ankylosing spondylitis (AS) is particularly strong, how HLA-B27 directly influences disease development has not yet been clearly explained, although hypotheses continue to be generated….

    Data Accumulate to Suggest HLA-B27 Status May Drive Axial Phenotype in SpA

    HLA-B27 may be a phenotypic expression of axial spondyloarthritis (SpA), according to a large international study. The study found patients with axial SpA who were positive for HLA-B27 had more severe radiographic damage than those who were negative for HLA-B27, and three quarters of study patients with ankylosis spondyloarthritis were HLA-B27 positive.

    Biophoto Associates / Science Source

    A Stiff Man: A Case Study in Ankylosing Spondylitis

    First Appearances I watched the old man, his back painfully bent, shuffle toward the scale. A blocky rigidity draped over him. His feet seemed stuck to the floor. His head hung heavily over his chest. Observing him from the end of the hallway, instead of a face, I saw only a mound of shaggy, matted…