Smart, Stem Cell-Based Implants May Revolutionize the Treatment of Arthritis

These custom-designed stem cells have the potential to provide auto-regulated drug delivery and enhanced tissue repair, thereby revolutionizing the treatment of arthritis.³

Lara C. Pullen, PhD, is a medical writer based in the Chicago area.

References

1. FT Moutos, KA Glass, SA Compton, et al. Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing. PNAS. 2016 Aug 2;113(31):E4513­–E4522.
2. JM Brunger, A Zutshi, VP Willard, et al. Genome engineering of stem cells for autonomously regulated, closed-loop delivery of biologic drugs. Stem Cell Rep. 2017 May 9;8(5):1202–1213.
3. F Guilak, L Pferdehirt, AK Ross, et al. Designer stem cells: Genome engineering and the next generation of cell‐based therapies. J Orthop Res. 2019 Jun;37(6):1287–1293.