Turbocharge Your Cell Analysis with Mass Cytometry

Information like this could prove powerful in developing and refining therapy, Dr. Bendall said.

“The idea is that we can build these models up where we can uncouple time and differentiation and division, look at what pathways are on and off, and when they’re on and off,” he said. “And [then we] start thinking about smart ways we can steer the cells into the phenotypes we want them to be.”

Thomas R. Collins is a freelance writer living in South Florida.

Reference

Qiu P, Simonds EF, Bendall SC, et al. Extracting a cellular hierarchy from high-dimensional cytometry data with SPADE. Nat Biotechnol. 2011 Oct 2;29(10):886-891.

A perspective on B cell–targeted therapies in autoimmune disease

This ACR Convergence session discussed how recent advances in single-cell technologies are being used in rheumatic disease research.

A review of data on antinuclear antibodies and tests for rheumatoid arthritis

SAN DIEGO—B cell signaling goes awry in many patients with systemic lupus erythematosus (SLE), triggering pathogenic autoimmune responses and clinical disease. At the Rheumatology Research Foundation’s 2017 Evelyn V. Hess Memorial Lecture, held on Nov. 5 at the ACR/ARHP Annual Meeting, researcher Ignacio Sanz, MD, discussed B cells’ role in this complex disease. Because lupus…

Reference

Is B a Key to Autoimmune Therapy?: B Cell–targeted Therapies in Autoimmune Disease

Single-Cell Technologies: A Path for New Insights

Laboratory Testing for Diagnosis, Management of Patients with Rheumatic Disease

Lupus B Cell Research Points Toward Targeted Therapies

Reference

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