Yao Syndrome: A Case Report & Clinical Review

1. In evaluating patients with episodic symptoms/manifestations, physicians need to be alert for autoinflammatory diseases;
2. Although SAIDs mostly occur in children, such disorders can present in adults;
3. Physicians need to recognize relatively new SAIDs beyond the hereditary periodic fever syndromes; and
4. Proper application of the periodic fever syndrome gene panel is helpful for early diagnosis, and enables reduction of unnecessary and repetitive testing. 

Peter Gorevic, MD, is a rheumatologist, professor of medicine, and former chair of the Department of Rheumatology, Icahn School of Medicine, Mount Sinai Hospital, N.Y.

Qingping Yao, MD, PhD, is a rheumatologist, Zhang Family Endowed Chair in Rheumatology, professor in the Department of Medicine, chief of the Division of Rheumatology, Allergy and Immunology, and director of the Center of Autoinflammatory Diseases, Stony Brook University Renaissance School of Medicine, N.Y.

Acknowledgments

The authors would like to thank Alan Kaell, MD, clinical professor of medicine at Stony Brook University, and Clara Abraham, MD, professor of medicine, Section of Digestive Diseases at Yale University, New Haven, Conn., for their kind review of the manuscript and comments. We are also thankful to Matthew Barish, MD, FACR, associate professor of clinical radiology, vice chair, Department of Radiology at Stony Brook University for his review of the CT images, and Ms. Lyn Hastings, communication specialist, Department of Medicine at Stony Brook University, for making the composite photograph.

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