“Gastric bypass associates with a reduced risk of PsO and PsA, possibly providing insights into metabolic correlates associated with PsO and PsA,” Dr. Solomon said. The results are only hypothesis generating, he cautioned.
Biologic DMARDs & Cancer Risk
Dr. Solomon said an observational study in JAMA Internal Medicine was important because “this is a typical patient question [for which] we need better data.”8
The study combined Swedish RA cohorts with cancer registries. Researchers found no increased cancer risk for TNF inhibitors across patients grouped by duration of use, even past four years of use. Researchers did find a “suggestion” of an increased risk with abatacept compared with TNF inhibitors for squamous cell skin cancers and melanoma, findings Dr. Solomon said “need further analysis.”
But overall, he said, “These results should increase confidence that TNF inhibitors are not associated with malignancy.”
Thomas R. Collins is a freelance writer living in South Florida.
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- Hinks A, Bowes J, Cobb J, et al. Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases. Ann Rheum Dis. 2017 Apr;76(4):765–772.
- Ridker PM, Everett BM, Thuren T, et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med. 2017 Sep 21;377(12):1119–1131.
- McAlindon TE, LaValley MP, Harvey WF, et al. Effect of intra-articular triamcinolone vs. saline on knee cartilage volume and pain in patients with knee osteoarthritis: A randomized clinical trial. JAMA. 2017 May 16;317(19):1967–1975.
- Egeberg A, Sørensen JA, Gislason GH, et al. Incidence and prognosis of psoriasis and psoriatic arthritis in patients undergoing bariatric surgery. JAMA Surg. 2017 Apr 1;152(4):344–349.
- Wadström H1, Frisell T1, Askling J, et al. Malignant neoplasms in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors, tocilizumab, abatacept or rituximab in clinical practice: A nationwide cohort study from Sweden. JAMA Intern Med. 2017 Nov 1;177(11):1605–1612.
