Patients with uncontrolled gout may benefit from a combination of pegloticase and methotrexate therapy, according to a small, retrospective study…
Myositis Autoantibodies: A Comparison of Serotyping Panels
The challenges of diagnosing myositis are numerous, with many tests resulting in false positives and negatives for autoantibody levels. Researchers recently compared a line blot array currently being used in research with the Oklahoma Medical Research Foundation Myositis panel, which is used in clinical testing. They found some patients were positive according to the research test, but negative according to the clinical test…
ACR Publishes Disease Activity and Functional Status Assessment Measure Recommendations for RA
The recommendations include updated disease activity measures and a new set of functional status assessment measures for rheumatoid arthritis.
Nailfold Videocapillaroscopy Provides a Window into Inflammatory Myopathies
A recent study investigated the possible differences in nailfold videocapillaroscopy in four types of inflammatory myopathies. Researchers observed giant capillaries, disorganization and major capillary loss in dermatomyositis and overlap myositis patients, finding dermatomyositis and overlap myositis imaging was different from that of antisynthetase syndrome and immune-mediated necrotizing myopathy…
Potential Link Between OA & Gout
Monosodium urate (MSU) crystal formation, deposition and gout flares frequently affect joints that have been damaged or are affected by osteoarthritis. These researchers examined the effects of human cartilage homogenates on MSU crystallization and MSU crystal-induced inflammation…
Tildrakizumab Promising for Psoriasis in Patients with PsA
New research shows tildrakizumab may significantly improve psoriasis in patients with active psoriatic arthritis…
New Consensus Recommendations Guide Sjögren’s Syndrome Management
NEW YORK (Reuters Health)—New consensus-based recommendations from the European League Against Rheumatism (EULAR) address the management of Sjögren’s syndrome with topical and systemic therapies. Sjögren’s syndrome presents with a broad spectrum of clinical manifestations and autoantibodies, including antinuclear antibodies (the most frequently detected), anti-Ro/SS-A (the most specific) and cryoglobulins and hypocomplementemia (the main prognostic markers)….
Rituximab-abbs Available in the U.S.; Plus Upadacitinib in Phase 3 Trials for PsA
Rituximab-abbs, which is biosimilar to rituximab, is now available in the U.S. to treat specific cancers…
Renal Transplant Outcomes in Patients with Lupus Nephritis
A recent study from Brazil suggests lupus nephritis patients who receive renal transplant have a high five-year survival rate. Researchers found the presence of venous thrombosis and antiphospholipid syndrome, but not viral infection, were important predictors of renal graft loss in these patients…
Progress on Preventing Immune-Related Adverse Events
ATLANTA—One of the hottest topics in medicine is the emerging field of cancer immunotherapy. However, immune-related adverse events (irAEs) are associated with the therapy, and when things go wrong, they can go very, very wrong, said Ryan Sullivan, MD, during the 2019 ACR/ARP Annual Meeting in November. “The guiding principle of cancer immunotherapy is [that]…
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