Recent research examined the effectiveness of a pedometer-based intervention for managing fatigue in patients with rheumatoid arthritis (RA). During the 21-week trial, RA patients using pedometers successfully increased their physical activity, with a greater than 30% decrease in the proportion of participants classified as sedentary. Patients also decreased their reported fatigue, and some reported improvements in function, pain, depressive symptoms and disease activity levels…
Etanercept’s New Autoinjection System; Plus FDA Approves Ixekizumab for Active PsA
In the U.S., a new formulation and an ergonomic delivery system for single doses of etanercept are now available for RA patients…
Many Doctors & Specialists Don’t Adhere to Fibromyalgia Diagnostic Criteria
NEW YORK (Reuters Health)—Generalist doctors, and even many specialists, have relatively poor knowledge of the American College of Rheumatology 1990 and 2010 fibromyalgia diagnostic criteria, according to results of a survey conducted in Canada. “Physicians do not have adequate and homogeneous knowledge of the fibromyalgia diagnostic criteria. Approximately half of physicians did not adhere to…
Vitamin D, Calcium Supplements May Not Lower Fracture Risk
(Reuters Health)—Older adults who take vitamin D and calcium are no less likely to break their hips or other bones than peers who don’t use these supplements, a research review suggests. Researchers examined data from 33 previous trials with a total of more than 51,000 people aged 50 or older who were living in the…
A Defect in Mitochondrial Function May Underlie Chronic Fatigue Syndrome
The peripheral blood mononuclear cells (PBMCs) of patients with chronic fatigue syndrome (CFS) may be unable to meet certain energetic demands, according to a U.K. study. Researchers found that PBMCs in healthy individuals may adapt to environmental stressors by enhancing their ability to increase ATP production through mitochondrial respiration, but not in patients with CFS…
Rituximab Use Increasing in Treatment of Pediatric Vasculitis
According to a large cohort study of pediatric patients, rituximab use is on the rise in the treatment of children diagnosed with vasculitis. Treatment with cyclophosphamide remains common, but it’s beginning to wane. Dialysis and mechanical ventilation also remain common, the study indicates. The retrospective study of hospitalized children in the U.S. included the largest…
Weight Change in Early RA & the Risk of Mortality
Sparks et al set out to investigate whether weight change during the early RA period is associated with subsequent mortality and to evaluate whether there is an RA-specific effect. They investigated weight change during the early RA period, because this is the window of time during which weight change is most likely to be related to RA-specific processes. They found that severe weight loss during the early RA period was associated with a subsequent increased mortality risk both for women with and without RA…
Does MRI Differentiate Osteoarthritis and Meniscal Tear in Knee Pain?
When a young patient arrives at a clinic complaining of knee pain with clicking or popping, a meniscal tear is often the culprit. “In young [people], there’s a pretty classic presentation of meniscal tear, with clicking and other mechanical symptoms, because the tear rubs up against different tissues,” says Jeffrey Katz, MD, MSc, a rheumatologist…
Long-Term Benefits, Risks of Biologic Disease-Modifying Anti-Rheumatic Drugs in Patients with RA
Two decades have passed since the first biologic disease-modifying anti-rheumatic drug (bDMARD) was approved. Studies on the long-term use of biologics in different disease states, such as for cardiovascular disease (CVD) and malignancy, as well as for knee/hip replacement, reveal some encouraging news. In clinical trials, bDMARDs have been shown to increase the risk of…
Rheumatology Drug Updates: Hip Fracture Rates After Bisphosphonate Drug Holidays, Plus More on Golimumab, Ustekinumab
Bisphosphonate Drug Holidays Drug holidays are common for patients on bisphosphonate therapy. Often, these breaks in treatment are related to known U.S. Food and Drug Administration (FDA) warnings and drug class adverse effects. Currently, data on fracture risk related to drug holidays are limited. In recent research highlighted at the 2017 ACR/ARHP Annual Meeting ,…
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