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Older Women Should Not Take Hormones to Prevent Chronic Diseases

Will Boggs MD  |  

(Reuters Health)— Postmenopausal women should not use hormone therapy to prevent chronic medical conditions, because the risk of significant side effects outweighs the unclear evidence of a benefit, according to a government-backed panel of experts. Most chronic conditions – coronary heart disease, dementia, stroke, fractures, and breast cancer, for example – are more common with…

Vitamin D-Metabolite Ratio Predicts Fracture Risk Better than 25(OH)D

Anne Harding  |  

NEW YORK (Reuters Health)—Vitamin D-metabolite ratio (VMR) may be a better marker of bone health than 25(OH)D (25-hydroxyvitamin D), a new study suggests. “The parameter that’s currently used to assess vitamin D status, 25(OH)D, is a flawed measure because it doesn’t consistently associate with important bone outcomes like hip fractures,” Dr. Charles Ginsberg of Veterans…

Knee Surgery Outcomes Linked with Education Level

Lisa Rapaport  |  

(Reuters Health)—Patients who live in low-income communities and lack a college education may have worse pain after knee replacement surgery than their more educated neighbors, a recent study suggests. Two years after total knee replacement surgeries, patients in poor communities who hadn’t gone to college had average pain scores that were about 10 points worse…

Safety, Tolerability & Pharmacodynamics of ABT-122 in Patients with RA

Arthritis & Rheumatology  |  

The introduction of biologic disease-modifying anti-rheumatic drugs (DMARDs) has greatly expanded the treatment options for managing rheumatoid arthritis (RA). In many patients, biologic DMARDs improve clinical symptoms, improve function and slow disease progression. Biologic DMARDs are recommended as add-on treatment to conventional synthetic DMARDs, such as methotrexate (MTX) in patients who experienced an incomplete response…

Lacrimal & Tear Fluid Yield Clues to Dry Eye Disease

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A recent study suggests novel markers of dry eye disease can be found in the lacrimal fluid and tear fluid of patients. Researchers analyzed the proteins in these fluids and found immune response-related proteins are upregulated at the protein level in lacrimal fluid of patients with dry eye disease and may be an important biomarker…

Obesity’s Effects on Inflammatory Markers in Patients with RA

Arthritis Care & Research  |  

New research has examined the effect of obesity on inflammatory markers, specifically C-reactive protein (CRP) level and erythrocyte sedimentation rate, in patients with rheumatoid arthritis (RA). Researchers found higher BMIs were associated with higher CRP levels in women both with and without RA, suggesting the phenomenon is related to adiposity and not an indication of disease activity. For men with RA, low BMI was associated with higher CRP levels, which proved to be RA-specific but not a direct causal effect of adiposity…

SIRT1: A Therapeutic Target for Osteoporosis?

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New research has found the sirtuin family of proteins may be a positive regulator of bone mass. In the study, pharmacological activation of SIRT1 in mice resulted in increased bone mass, suggesting the pharmacological activation of SIRT1 may protect against osteoporosis…