Otulipenia is a recently discovered autoinflammatory disease caused by germline mutations, which results in dysregulated ubiquitination in patients. In a small-scale study, researchers used exome sequencing and candidate gene screening to identify three different loss-of-function mutations in the OTULIN/FAM105B gene in patients…
(Reuters Health)—People with type 1 diabetes often develop other autoimmune disorders, such as thyroid and gastrointestinal diseases, and a recent study yields new information about this link. In the study, 27% of patients with type 1 diabetes had at least one other autoimmune disorder. But the new study also held some surprises about how early…
NEW YORK (Reuters Health)—Patients can develop rebound-associated vertebral fractures after stopping denosumab, a new report of nine cases shows. All of the patients were considered to be at low risk of fracture, and the fractures occurred within nine to 16 months of their last injection, Dr. Olivier Lamy and colleagues from Lausanne University Hospital in Switzerland…
NEW YORK (Reuters Health)—Gene expression and chromatin accessibility can be used to identify two Crohn’s disease (CD) molecular subclasses that match distinct disease phenotypes, researchers report. “The hope one day is to be able to test Crohn’s patients for the subtype of the disease they have, and thus determine which treatment should work best,” Dr….
(Reuters Health)—Many doctors who order computed tomography (CT) or magnetic resonance imaging (MRI) scans for patients with low back pain do so fearing that patients will be upset if they do not get imaging and because there is too little time to explain the risks and benefits of the tests, a new study found. The…
NEW YORK (Reuters Health)—Local infiltration of liposomal bupivacaine in patients undergoing total knee arthroplasty (TKA) curbed use of opioids and antiemetics and appeared to be both beneficial and cost effective in a recent study. As Dr. Bryan Sakamoto told Reuters Health by email, the results “suggest that liposomal bupivacaine is effective as part of a…
The use of proton pump inhibitors may lead to changes in bone mineral density and an increased risk of developing osteoporosis…
(Reuters Health)—Playing team sports, especially soccer, at the elite level may lead to a higher risk for osteoarthritis, but the existing research is of such low quality it’s hard to say for sure, according to a recent review. In an analysis of past studies filled with conflicting results, researchers found that long-distance running was the…
A study found that ixekizumab decreases disease activity and increases physical function in biologic-naive patients with active psoriatic arthritis…
We read the case report by Dr. Diana Girnita and colleagues (“Severe Refractory Gout: What options are left when pegloticase fails?” The Rheumatologist, August 2016) with interest. A case is reported of a subject with 20 years of chronic refractory gout who failed to respond to pegloticase therapy, and the potential roles of anti-drug antibodies or…