New research links the RNA binding protein Ro60 with SLE pathogenesis and disease-causing inflammation…
RA Patients on DMARDs Have Higher Risk of Infection
Preventing infection in patients with RA should be a consideration for rheumatologists prescribing disease modifying anti-rheumatic drugs after a Swedish study found patients on these therapies have a 6.1% risk of developing serious infection.
Online Tool Helps RA Patients Make Informed Decisions
Should you escalate care to a biologic? Many RA patients find this decision difficult and may need extra support and education to come to an informed decision. A recent study on this issue tested the value of a Web-based interactive decision support tool, which was developed with patient and physician input. After eight weeks, patients using the tool showed a measurable increase in the objective and subjective knowledge needed for making an informed decision compared with standard care…
Genetic Data Suggest Dividing IBD into 3 Forms
NEW YORK (Reuters Health)—Data from a genetic association study suggest that inflammatory bowel disease (IBD) should be divided into a three-group continuum, rather than the current division between Crohn’s disease and ulcerative colitis. “The current clinical classifications of IBD, while important and useful, are a simplification of the true biological variation of this disease,” Dr….
CD64 May Be an RA-Specific Biomarker
A new study found patients with early RA had increased membrane and soluble CD64. After receiving anti-rheumatic therapy, patients’ symptoms and CD64 levels decreased, suggesting CD64 is an RA biomarker…
Rectosigmoidoscopy vs. Colonoscopy for Assessing Ulcerative Colitis Activity
NEW YORK (Reuters Health)—In most cases, rectosigmoidoscopy and colonoscopy assessments of disease activity in ulcerative colitis yield the same results, researchers report. “In clinical practice, rectosigmoidoscopy is enough to assess endoscopic activity and endoscopic healing,” Dr. Jean-Frédéric Colombel from Icahn School of Medicine at Mount Sinai, N.Y., told Reuters Health by email. Dr. Colombel and…
Sleep Apnea Tied to Gout Flares
NEW YORK (Reuters Health)—Sleep apnea may increase the risk of developing gout and experiencing flare-ups, according to a new study. Until now, little was known about the relationship between the two conditions, the study team writes in an article online Oct. 19 in Arthritis & Rheumatology. Obesity plays an important role in both sleep apnea…
Low-Grade Inflammation in Symptomatic Knee OA
Although osteoarthritis (OA) was formerly considered a non-inflammatory joint disease, it’s now well-appreciated that inflammatory mediators, such as PGE2 and IL-1β, are produced by osteoarthritic joint tissues and can be used to identify patients with symptomatic knee OA. A peripheral blood leukocyte inflammatory transcriptome identifies a subset of symptomatic knee OA patients at higher risk for radiographic progression and may reflect persistent low-grade joint inflammation…
The Lupus Initiative Receives 5-Year CDC Grant
The Centers for Disease Control and Prevention (CDC) has awarded the American College of Rheumatology’s (ACR) The Lupus Initiative (TLI) with a five-year grant to support the development of a national, grassroots program targeting primary care providers, persons with undiagnosed Lupus and rheumatology health care providers. The program will have three components: Immediate dissemination of…
Genetic Screening May Prevent Adverse Gout Treatment Reaction
Screening gout patients for the HLA-B*58:01 allele may help rheumatologists determine more effective treatments and a patient’s risk of allopurinol-induced severe cutaneous adverse reactions…
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