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An official publication of the ACR and the ARP serving rheumatologists and rheumatology professionals

Other Rheumatic Conditions

Gene Expression Signature Useful for Diagnosing Kawasaki Disease

Will Boggs, MD  |  

NEW YORK (Reuters Health)—A 13-transcript whole-blood gene expression signature accurately differentiates Kawasaki disease (KD) from other febrile conditions in children, researchers report. “We believe it is feasible to turn the signature into a diagnostic test,” Dr. Michael Levin from Imperial College London, London, tells Reuters Health by email. “There are a range of methods to…

Study Results for 9 New Psoriatic Arthritis Drugs

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CHICAGO—As Eric Ruderman, MD, professor of medicine in rheumatology at Northwestern University Feinberg School of Medicine in Chicago, began his talk on psoriatic arthritis treatment at the ACR State-of-the-Art Clinical Symposium in April, he marveled a bit at how much there was to cover. Drugs gaining prominence in the treatment of rheumatoid arthritis and dermatological…

IgG4-Related Kidney Disease: Diagnostics, Manifestations, & More

IgG4-Related Kidney Disease: Diagnostics, Manifestations & More

Despina Michailidou, MD, PhD, & Paul Cohen, MD   |  

Immunoglobin G4-related disease (IgG4-RD) is a rare fibro-inflammatory disease of unknown etiology that has been recently recognized. It can cause fibro-inflammatory masses in almost every organ of the body and is associated with dense lymphoplasmacytic infiltration of IgG4-postitive plasma cells, storiform fibrosis and elevated levels of serum IgG4.1 IgG4-RD is a systemic disease that may…

The Latest Autoinflammatory Discoveries & Tips

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SAN DIEGO—Since the identification of the autoinflammatory disease, familial Mediter­ranean fever (FMF), researchers have identified an alphabet soup of other auto­inflammatory diseases with genetic underpinnings, from PAPA (pyogenic arthritis with pyoderma gangrenosum and acne) to NIAID (NLRP1-associated autoinflammation with arthritis and dyskeratosis) to TRAPS (TNF receptor-associated periodic syndrome). The torrent of discoveries, brought about largely…

An Amylodosis Warning & New Drug Hope

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SAN DIEGO—Treatments do exist that can improve the prospects of a patient with the rare disease amyloidosis, but only if clinicians keep the disease in mind and treat the patient before it’s too late, an expert said at the 2017 ACR/ARHP Annual Meeting this past November. He also discussed research that may be close to…

Gene Signatures in IgG4-Related Disease

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Research suggests prednisone treatment can selectively modulate the signatures of regulatory T (Treg) cells, eosinophils and neutrophils in patients with IgG4-related disease. The results show IgG4-related disease may result from an imbalance of immune and inflammatory cells…

Fibrotic Diseases of the Retroperitoneum & Skin, & Rare Scleroderma Mimics

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SAN DIEGO—Fibrosis affects all organ systems, but isn’t always systemic sclerosis. Experts on less common forms discussed patient presentations, diagnosis and treatment at the 2017 ACR/ARHP Annual Meeting in San Diego on Nov. 6. Retroperitoneal Fibrosis Formerly called Ormond’s disease, retroperitoneal fibrosis (RPF) is usually an IgG4-related disease, but has some unique characteristics, said John…