On Dec. 20, 2017, Congress passed a massive tax bill that will have an impact on nearly every individual and business in America. The bill makes sweeping revisions to existing tax provisions, and it will largely affect the health industry. Individual Mandate Repealed The bill repeals the individual mandate established in 2005 by the Affordable…
Chronic Pain Research Probes Neurologic Pain Pathways, Biomarkers
With the aid of increasingly sophisticated neuroimaging technology, research into how the brain activates and changes in patients with chronic pain is delivering fascinating information that will hopefully pave the way to tailored, individual treatment of chronic pain. Over the past several years, data from neuroimaging studies have provided a new understanding of what occurs…
Tips for Surviving FDA Audits of Your Clinical Trials
SAN DIEGO—You come to work. The day is going well. Your clinical trials are moving along. Then you get the call: It’s the Federal Drug Administration (FDA), and they’re coming to audit in about a week. You might be struck by a sense of dread. But you don’t have to be, an expert said at…
Turbocharge Your Cell Analysis with Mass Cytometry
SAN DIEGO—In his doctoral work, Sean Bendall, PhD, assistant professor of pathology and a researcher at Stanford University in Palo Alto, Calif., worked on protein identification and embryonic stem cell biology. That required examining the characteristics of cells—lots of cells. He was struck by how inefficient the process was. “The issue was, every experiment I…
3 Experts Discuss Bone Health
SAN DIEGO—At the 2017 ACR/ARHP Annual Meeting Nov. 3–8, experts discussed improving bone health in the U.S., gave tips on bone health disorders in pediatrics and reviewed new translational science findings for joint conservation in early osteonecrosis. E. Michael Lewiecki, MD, director of the New Mexico Clinical Research & Osteoporosis Center in Albuquerque, N.M., called…
DADA2 Research Reveals Mechanisms & Possible Gene Therapy
SAN DIEGO—An increasing number of patients is being identified with deficiency of adenosine deaminase type 2 (DADA2); fortunately, researchers and clinicians continue to better understand the genetic disease as well, experts said in a session at the 2017 ACR/ARHP Annual Meeting Nov. 3–8. The childhood-onset disease involves loss-of-function mutations to the CECR1 gene (i.e., cat…
Managing Myositis in 3 Different Scenarios
SAN DIEGO—In Hot Topics in Myositis, a session held Nov. 7 at the 2017 ACR/ARHP Annual Meeting, rheumatologists discussed treating myositis patients in three different clinical scenarios: persistently elevated creatine kinase (CK), immune-mediated necrotizing myopathies and lung disease. Elevated CK Patients with persistently elevated levels of CK enzyme and normal muscle strength “may still have…
Rheumatoid Arthritis Research Advances
SAN DIEGO—In a roundup of current research in rheumatoid arthritis (RA) presented at the 2017 ACR/ARHP Annual Meeting Nov. 3–8, Mark C. Genovese, MD, professor of medicine in the Division of Immunology and Rheumatology at Stanford University, Palo Alto, Calif., urged his audience to reflect on the impact therapy advances have made on RA. “In…
The Future of Rheumatoid Arthritis Treatment
SAN DIEGO—The next era of rheumatoid arthritis (RA) therapy could involve combining anti-tumor necrosis factor (anti-TNF) drugs with drugs that target molecules regulating the destructive potential of synovial fibroblasts, or even with anti-angiogenic drugs, said a pioneer of RA biologics therapy at the 2017 ACR/ARHP Annual Meeting Nov. 3–8. Ravinder N. Maini, MD, professor of…
International Rheumatology Training Challenges & Innovations
SAN DIEGO—Rheumatologists train in quite different ways depending on their global region, said panelists at a session sponsored by the International League of Associations for Rheumatology (ILAR) held at the 2017 ACR/ARHP Annual Meeting in San Diego on Nov. 7. Four association presidents shared training disparities and efforts to bridge gaps. EULAR: Consistency Challenges The…
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