Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a heterogeneous, inflammatory, musculoskeletal disease. The disease is an insidious, sterile osteitis with associated skin and synovial inflammation.1 Diagnosis can prove challenging, but a thorough clinical history, high clinical suspicion and imaging techniques can help clinch it. The below case reveals a rare, fulminant presentation of…
New research identifies how education designed to empower self-care and collaboration among providers, patients and family members can help patients with Sjögren’s syndrome manage their daily challenges and take back their lives…
A number of autoinflammatory syndromes that result from genetic mutations have been described recently. The vast majority occur in children. However, three periodic fever syndromes are important for rheumatologists who treat adults to know about. The goal of this review is to provide a concise description of each condition, and to help the clinician understand…
Tubulointerstitial nephritis and uveitis (TINU) syndrome, also known as Dobrin syndrome, is a rare oculo-renal inflammatory disease. It was first described in 1975 by American physician Robert Dobrin, MD.1 It manifests as acute interstitial nephritis and bilateral uveitis. In addition, patients often experience nonspecific systemic findings, such as fever, weight loss, malaise, myalgia and arthralgia. TINU…
(Reuters Health)—People with severe symptoms of chronic fatigue syndrome have a molecular signature in blood made up of 17 immune system signaling molecules that are elevated, which may provide insight into how inflammation contributes to the condition. “Of the 17 cytokines that correlated with severity, 13 are proinflammatory, likely contributing to many of the symptoms…
Patients with rheumatoid arthritis need a way to manage their fatigue outside of the standard treatment regime, says Patti Katz, PhD. “We found that increasing physical activity [by using a pedometer] did indeed make a difference in peoples’ fatigue level. … And it doesn’t make them hurt more.”…
The problem that dogs the work of all of those treating patients with antiphospholipid syndrome (APS) is the apparent lack of knowledge of the syndrome, both by the general public, as well as by swaths of the medical fraternity. Perhaps it was ever thus—a syndrome less than 40 years old could be described as new,…
Two case studies demonstrate the difficulty, delay in recognizing this rare autoinflammatory disease
Beyond biologic agents, scientists study cytokines, chemokines, and the interface between inflammatory and neural/secretory pathways
Research has led to greater understanding of the disease, potential for better treatment options