Allopurinol and Chronic Kidney Disease From the College | September 23, 2024 The CKD-FIX trial randomized 369 adults with stage 3 or 4 chronic kidney disease (CKD), no history of gout and an increased risk of CKD progression to receive allopurinol, up to 300 mg daily, or placebo. To learn more, review our article or take the quiz first. In a new-patient consultation for joint pain, you see a 75-year-old man with a history of dementia, stage 3a chronic kidney disease (CKD) and nephrolithiasis. He has a uric acid level of 7.5 mg/dL. His medication list includes 300 mg daily allopurinol. Which would not be an indication for allopurinol? Recurrent nontophaceous gout Recurrent urate nephrolithiasis Recurrent calcium oxalate nephrolithiasis Prevention of worsening proteinuric CKD None Time's up
