Know Your Cytokines From the College | August 19, 2024 During an acute gout flare, monosodium urate crystals are engulfed by resident synovial macrophages, activating the NLRP3 inflammasome. This causes the release of cytokines, which exacerbate pain, swelling and other gout manifestations. To learn more, review our article, or take the quiz first. Which cytokine is most elevated during an acute gouty flare? A. IL-1 B. IL-4 C. IL-10 D. IL-13 None Time's up
