Maxed Out Methotrexate? Staff | November 22, 2021 In early June, the ACR released an updated guideline on the management of rheumatoid arthritis, which includes new recommendations for specific high-risk groups. The guideline includes 44 recommendations—seven of which are strong and 37 conditional. It underscores the role of methotrexate as a cornerstone therapy and emphasizes minimizing glucocorticoids, when possible. To learn more, read the full article from The Rheumatologist, June 2021: The ACR Releases an Updated Treatment Guideline for Rheumatoid Arthritis. If a patient has maximized their methotrexate dose but is still not at target, the recommendation is to: A. add a biologic DMARD B. add a targeted synthetic DMARD C. add sulfasalazine and hydroxychloroquine D: A or B None Time's up