Urate Lowering Therapy: When to Start? From the College | April 25, 2024 The 2020 ACR Guideline for the Management of Gout includes recommendations on the indications for and optimal use of urate-lowering therapy (ULT). To limit potential side effects, including gout flare with ULT initiation, initiating low-dose ULT is recommended. For more key points from the guideline, review our article, or take the quiz first. What stage of chronic kidney disease is an indication to start urate-lowering therapy according to the 2020 ACR Guideline on the Management of Gout? A. CKD Stage 1 B. CKD Stage 2 C. CKD Stage 3 D. CKD Stage 4 None Time's up