VEXAS: A Newly Identified Disease Staff | June 30, 2021 A large, international team of rheumatologists, geneticists, hematologists and other researchers has discovered a severe inflammatory syndrome linked to an acquired genetic mutation. Peter Grayson, MD, MSc, the study’s co-senior author and a tenure-track investigator at the National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Md., says, “We have theorized for a long time that somatic or acquired mutations may cause rheumatic diseases, but this is really one of the first examples of that actually being identified.” Read the full article: “VEXAS: A Newly Identified & Vexing Myeloid-Driven Inflammation.” The Rheumatologist, December 2020. Which of the following is true of VEXAS syndrome? A. Cases are characterized by numerous white vacuoles on skin biopsy B. Its inheritance pattern is autosomal recessive C. It is an autoinflammatory disease associated with myelodysplasia, with varied clinical presentations D. It is caused by a mutation in an enzyme in the ubiquitylation pathway, UBA2 None Time's up
