Yao Syndrome

Review "Yao Syndrome: A Case Report & Clinical Review," The Rheumatologist, November 2020, before taking this month's quiz.

In evaluating patients with episodic symptoms/manifestations, physicians need to be alert for autoinflammatory diseases. Yao syndrome is characterized by periodic fever, dermatitis, arthritis and swelling of the distal extremities, as well as GI and sicca-like symptoms. Patients generally have flu-like symptoms, followed by episodic fever and erythematous patches or plaques with a pathological finding of spongiotic derma­titis. An episodic flare may last a few days to weeks, with an asymptomatic interval of several weeks or months. GI symptoms are common.