Case report: A 60-year-old Hispanic male with poorly controlled hypertension was sent from the primary care clinic for evaluation of malignant hypertension with a systolic blood pressure above 200 mmHg. His symptoms at the time of presentation included episodic confusion, worsening vision and an unsteady gait. A head computed tomography (CT) scan showed a subacute…
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Catastrophic Antiphospholipid Syndrome with Pulmonary Hemorrhage: A Case Report
Antiphospholipid syndrome (APS) is an autoimmune condition characterized by hypercoagulability often manifested as recurrent thrombosis or pregnancy complications, with persistently circulating antiphospholipid (aPL) antibodies or lupus anticoagulant. Catastrophic APS (CAPS), also known as Asherson syndrome, occurs in less than 1% of cases of APS and involves occlusive microangiopathy in at least three organ systems.1 Case…
Dermatology Symptoms Point to Connective Tissue Disorder
The Case A 68-year-old woman with a past medical history of Charcot-Marie-Tooth presents with thickening of the skin on her trunk and extremities, which she has had for the past seven months (see Figures 1 and 2). Her symptoms first began with swelling of her bilateral upper and lower extremities. She is now having difficulty…
Plaquenil: From Malaria Treatment to Managing Lupus, RA
In 1984, I wrote my first prescription for the antimalarial drug, hydroxychloroquine (Plaquenil), for a 28-year-old woman with SLE. She was considerably overweight, with inflammatory arthritis and a photosensitive rash, and I worried that oral corticosteroids would tip her over into diabetes. I presented the case to my attending, Steven Malawista, MD, at the Yale…
Cobalt Toxicity Complication of Hip Replacement Surgery
Rheumalogists urged to recognize toxicity symptoms in patients with metal-on-metal or metal-on-polyethylene hip implants
Malignant Atrophic Papulosis Is Challenging to Diagnose, Treat
Patient histories, clinician reports of condition also called Köhlmeier-Degos disease underscore need for integrated, multidisciplinary care
Why Antiphospholipid Antibody Syndrome Should Be On Your Radar
With a wide range of clinical manifestations and frequent occurrence among rheumatology patients, APS is one for rheumatologists to watch
ACR/ARHP Annual Meeting 2012: What Rheumatologists Need to Know about the New Oral Anticoagulants
A hematologist outlines how the new drugs can help treat coagulation triggered by rheumatological diseases
Antiphospholipid Antibody Testing Update
Successes, challenges, and controversies of diagnostic methods for APS
A&R Abstracts – HMGB1
For Further Reading