Research has shed light on the genetic mutations that link GDF5 with arthritis and height. An ancient regulatory variant in GROW1 has been repeatedly selected in humans in northern environments, explaining the high frequency of a GDF5 haplotype that increases arthritis susceptibility…
In a recent study, investigators examined the effects of both the short- and long-term use of selective serotonin-reuptake inhibitors (SSRIs) on the development and loss of bone. The study results describe the mechanisms by which SSRIs, specifically fluoxetine, affect osteoclasts short term to increase bone mass, but also how the treatment may cause bone loss at six weeks in mice…
New research describes the regulation of skeletal size and explores how cells sense, modify, and establish a volume set point.