The demonstrated connection between persistent effusion-synovitis and cartilage damage in certain osteoarthritis (OA) patients has implications for targeted treatment that updates previous OA treatment parameters…
Hyaluronidase 2 May Play an Important Role in OA Progression
A new study in mice found that Hyal2 deficiency may play a role in the turnover of cartilage hyaluronan, resulting in an accumulation of hyaluronan and, eventually, the development of osteoarthritis. Researchers suspect these results indicate an imbalance in the metabolism of hyaluronan…
Calcium Crystal Deposition in Rheumatic Diseases: Mechanisms & Evaluation of Calcium Crystal Deposits Explored
MADRID—Calcification in osteoarthritis (OA) involves a series of pathways and interactions that feed off each other in a process that bears some resemblance to the transformation of cartilage to bone that takes place in the embryonic stage of human development, a researcher said here at the 2017 Annual European Congress on Rheumatology (EULAR). “My hypothesis…
Adenosine Treatment Promotes Cartilage Homeostasis
A recent study in mice examined the role of adenosine A2A receptors in joint health. Researchers specifically found that as extracellular levels of adenosine fall, individuals may become at risk for osteoarthritis…
Can Nasal Tissue Be Used to Repair a Damaged Knee Joint?
(Reuters Health)—Doctors might one day be able to harvest cells from patients’ noses to produce cartilage that can be transplanted into damaged knee joints, a small experiment suggests. Because the experiment only included 10 adults who were followed for just two years, it’s impossible to say for sure whether this procedure would be safe or…
Can Childhood Fitness Predict Adult Knee Problems or OA?
An Australian study found an association between child physical performance measures and adult knee structures. The data, collected from three points in participants’ lives, revealed a link between childhood activity and adult tibial cartilage volume and bone area.
Vitamin C Derivative Promising Option for OA
New research in mice has found that treatment with a vitamin C derivative can effectively suppress the generation of mitochondrial superoxide, which plays a role in cartilage degeneration and the progression of osteoarthritis…
Telomere Length Provides Insights into Cartilage Aging and Repair
Chondrocyte telomere length might play a role in the natural aging of cartilage, as well as the development and progression of OA. (posted Oct. 8, 2013)
New Methodology to Improve Cartilage Repair
A single treatment with recombinant acid ceramidase improves the chondrogenic phenotype of primary chondrocytes and leads to an increased yield of mesenchymal stem cells. (posted July 31, 2013)
Can Lubricating Joints Prevent Osteoarthritis?
Proteoglycan 4 (Prg4), also known as lubricin, could slow the process of cartilage destruction in osteoarthritis. (posted June 13, 2013)