This ACR Convergence session discussed how recent advances in single-cell technologies are being used in rheumatic disease research.
Somatic Mosaicism Can Complicate Diagnosis of Autoimmune Disease
New methods of gene sequencing have resulted in improved identification of mutations in patients and increased availability of genetic testing in rare diseases. Despite these exciting advances, a majority of patients lack identifiable mutations and the underlying disease etiology remains an enigma. Somatic mosaicism (SM) may be an explanation for some of these clinically challenging…