New research has provided a never-before-seen view of the genetic activity that may be used to map the polygenic nature of common rheumatic diseases. Two recent studies have employed distinct approaches to identify the non-coding gene variants, digging deep into human genetic data to uncover the mechanism of rheumatic diseases…
In a large-scale genome-wide association study, researchers mapped 10 new SLE-associated loci and found aberrantly regulated gene expression networks may be behind SLE development…
The outcomes of genome-wide association studies (GWAS) have not been what scientists expected, but researchers are developing new approaches to use revelatory GWAS information to identify genetic causal variants, predictors of treatment response, and future opportunities for genetic insight.