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Articles tagged with "necrotizing myopathy"

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Did Shiitake Mushrooms Induce Immune-Mediated Necrotizing Myopathy?

Takeshi Yoshida, MD, Hiroaki Chikazawa, MD, Yoshitaka Kumon, MD, PhD, & Ichizo Nishino, MD, PhD  |  

Idiopathic inflammatory myopathies are heterogenous, acquired immune-mediated muscle diseases. Over the past decade, immune-mediated necrotizing myopathy has been recognized as a subcategory of idiopathic inflammatory myopathy characterized by myofiber necrosis in the absence of prominent inflammatory cells.1 Autoantibodies against signal recognition particle (SRP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are thought to be associated with the…

Managing Myositis in 3 Different Scenarios

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SAN DIEGO—In Hot Topics in Myositis, a session held Nov. 7 at the 2017 ACR/ARHP Annual Meeting, rheumatologists discussed treating myositis patients in three different clinical scenarios: persistently elevated creatine kinase (CK), immune-mediated necrotizing myopathies and lung disease. Elevated CK Patients with persistently elevated levels of CK enzyme and normal muscle strength “may still have…