FDA Approves Upadacitinib for Non-Radiographic Axial Spondyloarthritis Michele B. Kaufman, PharmD, BCGP | October 27, 2022The FDA has approved upadacitinib for the treatment of non-radiographic axial spondyloarthritis (nr-axSpA) based on a short-term study that demonstrated improved pain, function and other symptoms of nr-axSpA in patients with active disease.