SAN FRANCISCO—What factors help determine whether or not inflammation resolves, leading to healing, or becomes chronic, leading to disease and tissue destruction? A number of important cells, including toll-like receptors, mast cells, anti-citrullinated protein antibodies, complement and interferon, all play their own role in this process. By understanding how they act in innate and adaptive…
SAN FRANCISCO—The Kveim-Siltzbach skin test for a diagnosis of sarcoidosis was developed in 1941, then popularized in 1961. Since then, the knowledge base about the disease has not expanded much, said Kristin Highland, MD, who has dual appointments at Cleveland Clinic’s Respiratory Institute and Orthopedics and Rheumatology Institute. “We don’t know a whole lot more…
SAN FRANCISCO—Evolving research into the pathogenesis of rheumatoid arthritis (RA) is increasingly showing that rather than a single causative dysfunctional pathway leading to disease, multiple pathways are involved, the study of which can shed additional light on what is occurring in a person’s body prior to developing symptoms of disease. Saying it another way, no…
Overview of OA pathogenesis, recent discoveries suggest new treatment strategies are possible
Topical application of protein tyrosine kinase inhibitors shown to reverse mouse model of the disease
A new study suggests that intestinal expansion of Prevotella copri may be associated with the pathogenesis of RA
Studies determine that both RA and PsA are autoimmune diseases and link disease susceptibility to certain alleles that encode the major histocompatibility complex, HLA
Funds help scientists explore role of neutrophil extracellular traps in the pathogenesis of RA
Research into scleroderma, fibrosis, and Raynaud’s phenomenon may provide clues into the pathogenesis of systemic sclerosis
Experts discuss insights in the pathogenesis of psoriatic arthritis and the role of subchondral bone in osteoarthritis